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Latest news: A press release by the International Society on Aging and Disease (ISOAD), Shanghai University, Chinese Academy of Medical Sciences & Peking Union Medical College, China:

A groundbreaking new therapeutic approach was developed and tested to improve outcome in patients suffering from novel coronavirus (COVID-19) pneumonia. The new technique involves intravenous transplantation of mesenchymal stem cells (MSCs) into the patients. It was successfully tested in 7 COVID-19 patients, in Beijing YouAn Hospital, Capital Medical University, China. The results are published in the scientific journal Aging and Disease, entitled “Transplantation of ACE2- Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia” (free on line):

The study was conducted by a team led by Dr. Zhao, with Shanghai University and Chinese Academy of Medical Sciences & Peking Union Medical College, China.

MSCs could cure or significantly improve the functional outcomes of all the seven tested patients without observed adverse effects, contrary to 3 controls. The pulmonary function and symptoms of these seven patients were significantly improved after MSC transplantation. Among them, one severe and two common patients recovered and were discharged in 10 days after the treatment.

The presented evidence suggests that the therapeutic effects are based on the immunomodulatory capacity of mesenchymal stem cells (restoring the balance of the immune system). The coronavirus infection can stimulate a terrible cytokine storm in the lung, disrupting the balance of cytokines (signaling molecules of the immune system) such as IL-2, IL-6, IL-7, GSCF, IP10, MCP1, MIP1A and TNFα cytokines, followed by the edema, dysfunction of the air exchange, acute respiratory distress syndrome, acute cardiac injury and the secondary infection, which may lead to death. MSCs could inhibit the over-activation of the immune system and promote endogenous repair by improving the microenvironment, thus they could represent a safe and effective treatment for patients with COVID-19 pneumonia, especially for the patients in critically severe conditions.

Notably, the coronavirus-infected pneumonia is more likely to affect older individuals, especially older males, with comorbidities, resulting in their severe and even fatal respiratory diseases such as acute respiratory distress syndrome. In other words, aging appears to be the main risk factor for bad outcomes. However, the cure essentially depends on the patient’s own immune system. When the overactivated immune system kills the virus, it produces a large number of inflammatory factors, leading to the severe cytokine storms. This suggests that the main reason for the organs damage may be the virus-induced cytokine storm. Older subjects may be much easier to be affected due to immunosenescence. The study showed remarkable recovery of the elderly patients thanks to restoring their immune function.

Thus, the study may have a broader significance, even beyond the treatment of the severe coronavirus disease. This study exemplifies that the general therapeutic improvement of the immune system in the elderly can improve outcome and survival, which may have more general relevance for other aging-related communicable diseases. Thus, this study may inspire and pave the way for further promising directions to investigate the connection between aging and disease, and to treat both communicable and non-communicable aging-related diseases.

Bored Panda reports:

The spread of the new coronavirus around the world is bringing out the best in some people. 17-year-old high school senior Avi Schiffmann living in Washington state created a website to monitor the coronavirus, as well as to provide facts about the illness.

The teenager is incredibly dedicated to his project: he spends up to 6 hours each day to improve the website that has millions of views. Before the second version of his website went live, he spent the entire weekend in his room, working through the night and staying up until 7 AM.

Bored Panda spoke with The Doctors’ Association UK to learn more about the virus, how it spreads, and who is most vulnerable to the illness. Scroll down and read on for the informative interview.

More info: ncos2019.live | Instagram

Meet 17-year-old Avi Schiffmann. He created a website that tracks the spread of the coronavirus and provides facts about the illness

Image credits: avischiffmann

Avi, who goes to Mercer Island High School, launched his website in December 2019 and has been tinkering with it ever since. His website updates the number of people affected by the illness every 10 minutes by collecting and cross-referencing data from sources such as the World Health Organization, the Centers for Disease Control and Prevention, as well as local health departments.

Avi’s website has been visited millions of times

Image credits: ncov2019.live

“I thought it would be cool if there was a website that could pull in all the information from all kinds of sources,” the teenager told TODAY. “I mainly wanted to create something that would show the data as accurately as possible because there has been a lot of misinformation.”

He continued: I’m always adding new features. It’s going to adapt as it goes along. In the future, it might be less interesting to know there are five cases in France. We might be more interested in knowing the percentage increase from last week to this week.”

It provides up-to-date information about the coronavirus…

Image credits: ncov2019.live

According to the teen, people send him messages if they spot anything inaccurate. “A while ago, there was a massive bug, where it doubled all the numbers of coronavirus cases. And I got hundreds of messages. But overall, I’ve done a good job of managing my server.”

He also included the numbers of people who’ve recovered from the coronavirus to show a more nuanced picture of the situation.

…and updates regularly

Image credits: ncov2019.live

Avi crossreferences information about the illness from multiple reliable sources

Image credits: ncov2019.live

Image credits: ncov2019.live

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